Original Articles

1. Qiu, Z., Minegishi, T., Aoki, D., Abe, K., Baba, K., Inagaki, N., Adhesion-clutch between DCC and netrin-1 mediates netrin-1–induced axonal haptotaxis, Front Mol Neurosci, 17:1307755 (2024)
2. Fujikawa, R., Okimura, C., Kozawa, S., Ikeda, K., Inagaki, N., Iwadate, Y., Sakumura, Y., Bayesian traction force estimation using cell boundary-dependent force priors, Biophys. J, 122, 4542–4554 (2023)
3. Anggraini, D., Zhang, T., Liu, X., Okano, K., Tanaka, Y., Inagaki, N., Li, M., Hosokawa, Y., Yamada, S., Yalikun, Y., Guided axon outgrowth of neurons by molecular gradients generated from femtosecond laser-fabricated micro-holes, Talanta 267, 125200 (2023)
4. Kastian, RF., Baba, K., Kaewkascholkul, N., Sasaki, H., Watanabe, R., Toriyama, M., Inagaki, N., Dephosphorylation of neural wiring protein shootin1 by PP1 phosphatase regulates netrin-1-induced axon guidance. J Biol Chem., 299, 104687 (2023)
5. Minegishi, T., Fujikawa, R., Kastian, RF., Sakumura, Y., Inagaki, N., Analyses of actin dynamics, clutch coupling and traction force for growth cone advance. J. Vis. Exp. e63227 (2021)
6. Kastian, RF., Minegishi, T., Inagaki, N., Simultaneous analyses of clutch coupling and actin polymerization in dendritic spines during chemical LTP. Star Protoc. 2, 100904 (2021)
7. Abe, K., Baba, K., Huang, L., Koay, TW., Okano, K., Hosokawa, Y. and Inagaki, N., Mechanosensitive Axon Outgrowth Mediated by L1–Laminin Clutch Interface. Biophys. J. 120, 3566-3576 (2021)
8. Kastian, RF., Minegishi, T., Baba, K., Saneyoshi, T., Katsuno-Kambe, H., Saranpal, S., Hayashi, Y. and Inagaki, N., Shootin1a-mediated actin-adhesion coupling generates force to trigger structural plasticity of dendritic spines, Cell Rep. 35, 109130 (2021)
9. Masuda, T., Hirose, H., Baba, K., Walrant, A., Sagan, S., Inagaki, N., Fujimoto, T. and Futaki, S., An artificial amphiphilic peptide promotes endocytic uptake by inducing membrane curvature, Bioconjug Chem. 31, 1611-1615 (2020)
10. Urasaki, A., Morishita, S., Naka, K., Uozumi, M., Abe, K., Huang, L., Watase, E., Nakagawa, O., Kawakami, K., Matsui, Y., Bessho, Y., and Inagaki, N.(2019). Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system, Sci. Rep. 9:12156 .
11. Huang, L., Urasaki, A. and Inagaki N.(2019). Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain, Sci. Rep. 9:1799.
12. Masuda, T., Baba, K., Nomura, T. Tsujita, K., Murayama, T., Itoh, T., Takatani-Nakase, T., Sokabe, M., Inagaki, N. and Futaki, S. (2019). An influenza-derived membrane tension-modulating peptide regulates cell movement and morphology via actin remodeling, Communications Biology 2:243 .
13. Minegishi, T., Uesugi Y., Kaneko N., Yoshida W., Sawamoto K.and Inagaki, N. (2018). Shootin1b mediates a mechanical clutch to produce force for neuronal migration, Cell Reports 25, 624-639
14. Baba, K., Yoshida, W., Toriyama, M., Shimada, T., Manning, C.F., Saito, M., Kohno, K., Trimmer, J.S., Watanabe, R., and Inagaki, N. (2018). Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance. eLife 2018;7:e34593.
15. Abe, K., Katsuno, H., Toriyama, M., Baba, K., Mori T., Hakoshima T, Kanemura Y., Watanabe, R. and Inagaki, N.,Grip and slip of L1-CAM on adhesive substrates direct growth cone haptotaxis, Proc. Natl. Acad. Sci. USA, 115, 2764-2769 (2018)
16. Higashiguchi, Y., Katsuta, K., Minegishi, T., Yonemura, S., Urasaki, A., Inagaki N., Identification of a shootin1 isoform expressed in peripheral tissues, Cell Tissue Res. 366, 75-87 (2016)
17. Tahara, K., Tsukui, M., Maeno, T., Inagaki N., Kikuchi, J. “Efficient Solid-Phase Gene Delivery Mediated by Cerasome: Effect of Reverse Procedure on Transfection Performances in Comparison with Solution-Based Method”, Chem. Lett. 44, 1643-1645 (2015)
18. Kubo, Y., Baba, K., Toriyama, M., Minegishi, T., Sugiura, T., Kozawa, S., Ikeda, K., and Inagaki N., Shootin1-cortactin interaction mediates signal-force transduction for axon outgrowth. J. Cell Biol. 210, 663-676 (2015)
19. Katsuno, H., Toriyama, M., Hosokawa, Y., Mizuno, K., Ikeda, K., Sakumura, Y, and Inagaki N., Actin migration driven by directional assembly and disassembly of membrane anchored actin filaments, Cell Reports 12, 648-660 (2015)
20. Toriyama M., Kozawa S., Sakumura Y. and Inagaki N., Conversion of a signal into forces for axon outgrowth through Pak1-mediated shootin1 phosphorylation, Curr. Biol. 23, 529-534 (2013)
21. Kozawa S., Sakumura Y., Toriyama M., Inagaki N., Ikeda K., Bayesian cell force estimation considering force directions, Neural Processing Letters, DOI 10.1007/s11063-013-9320-y (2013)
22. Tahara K., Moriuchi T., Tsukui M., Hirota A., Maeno T., Toriyama M., Inagaki N., Kikuchi J., Ceramic coating of liposomal gene carrier for minimizing toxicity to primary hippocampal neurons, Chem. Lett. 42, 1265-1267 (2013)
23. Nakazawa H., Sada T., Toriyama M., Tago K., Sugiura T., Fukuda M., Inagaki N., Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth, J. Neurosci. 32, 12712-12725 (2012)
24. Hirano Y., Hatano T., Takahashi A., Toriyama M., Inagaki N., Hakoshima T., Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain, EMBO J. 30, 2734-2747 (2011)
25. Akashi K., Yoshida K., Kuwano M., Kajikawa M., Yoshimura K., Hoshiyasu S., Inagaki N., Yokota, A., Dynamic changes in the leaf proteome of a C3 xerophyte, Citrullus lanatus (wild watermelon), in response to water deficit, Planta 233, 947 (2011)
26. Toriyama M., Sakumura Y., Shimada T., Ishii S., Inagaki N., A diffusion-based neurite length sensing mechanism involved in neuronal symmetry-breaking, Mol. Sys. Biol. 6, 394 (2010)
27. Yamatani H., Kawasaki T., Mita S., Inagaki N., Hirata T., Proteomics analysis of temporal changes in axonal proteins during maturation, Dev. Neurobiol. 70, 523-537 (2010)
28. Shimada T., Toriyama M., Uemura K., Kamiguchi H., Sugiura T., Watanabe N. and Inagaki N., Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth, J. Cell Biol. 181, 817-829 (2008)
29. Mori T., Wada T., Suzuki T., Kubota Y., Inagaki N., Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity, J. Biol. Chem. 282, 19884-19893 (2007)
30. Tanii I., Yagura T., Inagaki N., Nakayama T., Imaizumi K., Yoshinaga K., Preferential localization of rat GAPDS on the ribs of fibrous sheath of sperm flagellum and its expression during flagellar formation, Acta Histochem. Cytochem. 40, 19-26 (2007)
31. Toriyama M., Shimada T., Kim K.B., Mitsuba M., Nomura E., Katsuta K., Sakumura Y., Roepstorff, P., Inagaki N., Shootin1: a protein involved in organization of an asymmetric signal for neuronal polarization, J. Cell Biol. 175, 147-157 (2006)
32. Katano T., Mabuchi T., Okuda-Ashitaka E., Inagaki N., Kinumi T., Ito S., Proteomic identification of a novel isoform of collapsin response mediator protein (CRMP-2) in spinal nerves peripheral to dorsal root ganglia, Proteomics 8, 6085-6094 (2006)
33. Oguri T., Inoko A., Shima H., Izawa H., Arimura N., Yamaguchi T., Inagaki N., Kaibuchi K., Kikuchi K., Inagaki M., Vimentin-Ser82 as a memory phosphorylation site in astrocytes, Genes to Cells 11, 531-540 (2006)
34. Nomura E., Katsuta K., Ueda T., Toriyama M., Mori T. Inagaki N., Acid-labile surfactant Improves In-solution dodecyl sulfate polyacrylamide gel protein digestion for matrix-assisted laser desorption/ionization mass spectrometric peptide mapping, J. Mass Spectrometry 39 202-207 (2004)
35. Suzuki Y., Nakagomi S., Namikawa K., Kiryu-Seo S., Inagaki N., Kaibuchi K., Aizawa H., Kikuchi K. Kiyama H., Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat, J. Neurochem. 86, 1042-1050 (2003)
36. Oguri T., Takahata I., Katsuta K., Nomura E., Hidaka M., Inagaki N., Proteome analysis of rat hippocampal neurons by multiple large gel two-dimensional electrophoresis, Proteomics 2, 666-672 (2002)
37. Fukata Y., Itoh T.J., Kimura T., Menager C., Nishimura T., Shiromizu T., Watanabe H., Inagaki N., Iwamatsu A., Hotani H., Kaibuchi K., CRMP-2 binds to tubulin heterodimers to promote microtubule assembly, Nature Cell Biol. 4, 583-591 (2002)
38. Inagaki N., Chihara K., Arimura N., Menager C., Kawano Y., Matsuo N., Nishimura T., Amano M., Kaibuchi K., CRMP-2 induces axons in cultured hippocampal neurons, Nature Neurosci. 4, 781-782 (2001)
39. Taya S., Inagaki N., Sengiku H., Makino H., Iwamatsu A., Urakawa I., Nagano K., Kataoka S., Kaibuchi K., Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF, J. Cell Biol. 155, 809-819 (2001)
40. Canossa M., Gartner A., Campana G., Inagaki N., Thoenen H., Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI)- and Trk-receptor activation is mediated via phospholipase C signaling pathways, EMBO J. 20, 1640-1650 (2001)
41. Inagaki N., Nishizawa M., Arimura N., Yamamoto H., Takeuchi Y., Miyamoto E., Kaibuchi, K. Inagaki M. Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons, J. Biol. Chem. 275, 27165-27171 (2000)
42. Arimura N., Inagaki N., Chihara K., Menager C., Nakamura N., Amano M., Iwamatsu A., Goshima Y., Kaibuchi K., Phosphorylation of collapsin response mediator protein-2 by Rho-kinase: evidence for two separate signaling pathways for growth cone collapse, J. Biol. Chem., 275, 23973-23980 (2000)
43. Ming G.-i., Song H.-j., Berninger B., Inagaki N., Tessier-Lavine M., Poo M.-m., Phospholipase C- γ and phosinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance, Neuron 23, 139-148 (1999)
44. Yasui Y., Amano M., Nagata K.-i., Inagaki N., Nakamura H. Saya H., Kaibuchi K., Inagaki M., Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments, J. Cell Biol. 143, 1249-1258 (1998)
45. Kamei Y., Inagaki N., Nishizawa M., Tsutsumi O., Taketani Y., Inagaki M. Visualization of mitotic radila glial lineage cells in the developing rat brain by cdc2 kinase-phosphorylated vimentin, Glia 23, 191-199 (1998)
46. Inagaki N., Goto H., Ogawara M., Nishi Y., Ando S., and Inagaki M., Spatial patterns of Ca2+ signals define intracellular distribution of a signaling by Ca2+/calmodulin-dependent protein kinase II, J. Biol. Chem. 272, 25195-25199 (1997)
47. Inagaki N., Nishizawa M., Ito M., Fujioka M., Nakano T., Tsujino S., Matsuzawa K., Kimura, K., Kaibuchi K., Inagaki, M., Miosin binding subunit of smooth muscle myosin phosphatase at the cell-cell adhesion sites in MDCK cells, Biochem. Biophys. Res. Commun. 230, 552-556 (1997)
48. Takizawa N., Mizuno Y., Komatsu M., Matsuzawa S.-I., Kawamura T., Kawamura T., Inagaki N., Inagaki M., and Kikuchi K., Alterations in type-1 serine/threonine protein phosphatase PP1a in response to B-cell receptor stimulation, J. Biochem. 122, 730-737 (1997)
49. Ito M., Feng J., Tsujino S., Inagaki N., Inagaki M., Tanaka J., Ichikawa T., Hartshorne D.J. and Nakano T., Interaction of smooth muscle myosin phosphatase with phospholipids, Biochemistry 36, 7607-7614 (1997)
50. Matsuzawa K., Kosako H., Inagaki N., Shibata H., Mukai Y., Ono Y., Amano M., Kaibuchi K., Matsuura I., Azuma I., Inagaki M., Domain specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN, Biochem. Biophys. Res. Commun. 234, 621-625 (1997)
51. Meijer L., Borgne A., Mulner O., Chong J.P.J., Blow J.J., Inagaki N., Inagaki M., Delcros J.-G., Moulinoux J.-P., Biochemical and cellular effects of roscovine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5, Eur. J. Biochem. 243, 527-536 (1997)
52. Sekimata M., Tsujimura K., Tanaka J., Takeuchi Y., Inagaki N., Inagaki M., Detection of protein kinase activity specifically activated at metaphase-anaphase transition, J. Cell Biol. 132, 635-641 (1996)
53. Tsujino S., Sekimata M., Inagaki N., Kamei Y., Higashihara M. Kurokawa K., Imajoh-Ohmi, S., Inagaki, M., Primary structure of light and heavy chain variable regions of antibodies recognizing phosphorylated vimentins, Biochem. Biophys. Res. Commun. 129, 633-637 (1996)
54. Ogawara M.#, Inagaki N.# (#Equal contribution), Tsujimura K., Takai Y., Sekimata M., Ha M.H., Imajoh-Ohmi S., Hirai S., Ohno S., Sugiura H., Yamauchi T., Inagaki M., Differential targeting of protein kinase C and CaM kinase II signalings to vimentin, J. Cell Biol. 131, 1055-1066 (1995)
55. Zirrgiebel U., Ohga Y., Carter B., Berninger B., Inagaki N., Thoenen H., and Lindholm D. Characterization of TrkB receptor-mediated signaling pathways in rat cerebellar granule neurons: involvement of protein kinase C in neuronal survival, J. Neurochem. 65, 2241-2250 (1995)
56. Inagaki N., Thoenen H., Lindholm D., TrkA tyrosine residues involved in NGF-induced neurite outgrowth of PC12 cells, Eur. J. Neurosci. 7, 1125-1133 (1995)
57. Kondou H., Inagaki N., Fukui H., Formation of inositol phosphates by M2 muscarinic receptors in type-1 and type-2 astrocytes from neonatal rat cerebral cortex, Neurosci. Lett. 180, 131-134 (1994)
58. Berninger B., Garcia D.E., Inagaki N. Hahnel C., Lindholm D., BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurons, NeuroReport 4, 1303-1306 (1993)
59. Panula P., Takagi H., Inagaki N., Yamatodani A., Tohyama M. Wada, H., Kolitainen, E. Histamine-containing nerve fibers innervate human cerebellum, Neurosci. Lett. 160, 53-56 (1993)
60. Mochizuki, T., Yamatodani, A., Okakura, K., Horii, A., Inagaki, N., and Wada, H., Circadian rhythm of histamine release from the hypothalamus of freely moving rats, Physiol. Behave. 51,391-394 (1992)
61. Ito S., Sugama K., Inagaki N., Fukui H., Giles H., Wada H., Hayaishi, O., Type-1 and type-2 astrocytes are distinct targets for prostaglandines D2, E2, and F2 , Glia 6, 67-74 (1992)
62. Miki H., Inagaki N., Yamatodani A., Wada H., Regional distribution of histamine in the brain of non-mammalian vertebrates, Brain Res. 571, 129-132 (1992)
63. Inagaki N., Fukui H., Ito S., Yamatodani A., Wada H., Single type-2 astrocytes show multiple independent sites of Ca2+ signaling in response to histamine, Proc. Natl. Acad. Sci. USA 88, 4215-4219 (1991)
64. Inagaki N., Panula P., Yamatodani A., Wada, H., Organization of the histaminergic neuron system in the brain of the teleost, Trachurus trachurus, J. Comp. Neurol. 310, 94-102 (1991)
65. Inagaki N., Fukui H., Ito S., and Wada H., Type-2 astrocytes show Ca2+ elevation in response to various neuroactive substances, Neurosci. Lett. 128, 257-260 (1991)
66. Mochizuki T., Yamatodani A., Okakura K., Takemura M., Inagaki N., and Wada H., In vitro release of neuronal histamine in the hypothalamus of rats measured by microdialysis, Naunyn-Schmiedeberg's Arch Pharmacol. 343, 190-195 (1991)
67. Kondou H., Inagaki N. Fukui H., Koyama Y., Kanamura A., Wada, H., Histamine-induced inositol phosphate accumulation in type-2 astrocytes, Biochem. Biophys. Res. Comm. 177, 734-748 (1991)
68. Kubo A., Fukui H., Inagaki N., Kanamura A., Wada, H., Histamine-induced cyclic AMP accumulation in type-1 and type-2 astrocytes in primary culture, Eur. J. Pharmacol. 208, 249-253 (1991)
69. Inagaki N., Panula P., Yamatodani A., Wada H., Organization of the histaminergic system in the brain of the turtle, Chinemys reevesii, J. Comp. Neurol. 297, 132-144 (1990)
70. Inagaki N., Toda K., Taniuchi I., Panula P., Yamatodani A., Tohyama M., Watanabe T., Wada H., An analysis of histaminergic efferents of the tuberomammillary nucleus to the medial preoptic area and inferior colliculus of the rat, Exp. Brain Res. 80, 374-380 (1990)
71. Inagaki N., Fukui H., Taguchi Y., Wang N.P., Yamatodani A., Wada H., Characterization of histamine H1-receptors on astrocytes in primary culture: [3H]mepyramine binding studies, Eur. J. Pharmacol. 173, 43-51 (1989)
72. Inagaki N., Yamatodani A., Shinoda K., Panula P., Watanabe T., Shiotani Y., Wada H., Histaminergic nerve fibers in the median eminence and hypophysis of rats demonstrated immunocytochemically with antibodies against histidine decarboxylase and histamine, Brain Res. 439, 402-405 (1988)
73. Inagaki N., Yamatodani A., Ando-Yamamoto M., Tohyama M., Watanabe T., Wada H. Organization of histaminergic fibers in the rat brain, J. Comp. Neurol. 273, 283-300 (1988)
74. Inagaki N., Kamisaki Y., Kiyama H., Horio Y., Tohyama M., Wada H., Immunocytochemical localizations of cytosolic and mitochondrial glutamic oxaloacetic transaminase isozymes in rat primary sensory neurons as a marker for the glutaminergic neuronal system, Brain Res. 402, 197-220 (1987)
75. Inagaki N., Yamatodani A., Shinoda K., Shiotani Y., Tohyama M., Watanabe T., Wada, H. The histaminergic innervation of the mesencephalic nucleus of the trigeminal nerve in rat brain: a light and electron microscopical study, Brain Res. 418, 388-391 (1987)
76. Inagaki N., Kamisaki Y., Kiyama H., Horio Y., Tohyama M., Wada H. Immunocytochemical localizations of cytosolic and mitochondrial glutamic oxaloacetictransaminase isozymes in rat retina as a markers for the glutamate-aspartate neuronal system, Brain Res. 325, 336-339 (1985)